132 research outputs found

    Storia della Scrittura e Storia della Società

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    The author gives a scoop of the studies, led during the last forty years, by all kinds of experts, and from different points of view, on the relation between writing and social structure. Directed at the beginning by linguists such as M. Cohen and by East European experts who follow the marxist trend, these ideas have given birth on the one hand to a wide range of historical studies about elimination of illiteracy and, on the other hand, to strictly palaeographic theses to study the function of the document and of writing for ancient and medieval societies.L'auteur trace ici un tableau des études qui, tout au long de ces quarante dernières années, ont reconsidéré, sous differents angles, et en main d'experts de différentes formations, la relation entre l'écriture et les structures sociales. Dirigées, en principe, par des linguistes tel que M. Cohen et par des experts de formation et d'influence marxiste originaires de pays d'Europe de l'Est, ces idées ont donné vie, d'une part, à une plus ample série d'études historiques de l'alphabétisme et, d'autre part, à des thèses proprement paléographiques destinées à étudier la fonction de l'écrit et de l'écriture dans les sociétés anciennes et médiévales

    Escrituras marginales y escribientes subalternos

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    La presencia en una sociedad de tipologías escriptorias elementales y de las pertenecientes a las clases subalternas parcialmente alfabetizadas no puede ser interpretada en un modo rígidamente secuencial; los ejemplos suministrados por dos momentos particulares de la historia de la Europa moderna, el paso del Cuatrocientos al Quinientos, y del Setecientos al Ochocientos, confirman la necesidad de una aproximación crítica adecuada a la complejidad del problemaLa présence dans une société de typologies d'écritures élémentaires et de celles qui concernent les classes subalternes partiellement alphabétisées ne peut être interprétée d'une façon rigidement séquentielle; les exemples fournis par deux moments particuliers de l'histoire de l'Europe moderne, le passage du XIVème au XVème, et du XVIIème au XVIIIème, confirment la nécessité d'une approche critique appropriée á la complexité d'un problèmeDie Existenz an einer Gesellschaft schriftlicher grundlegenden Typologien und die der untergeordneten und teilweise alphabetisierten Schichten kann nicht einfach hintereinanderfolgend interpretiert werden. Zwei konkreten, der europaischen Geschichte angehórenden Beispielen, der Uebergang vom 15. zum 16. Jahrhundert und der vom 18. zum 19. Jahrhundert, bestatigen den Bedarf an einer kritischen, der Verwicklung des Problems angemessenen AnnaherungThe presence in a society of elementary handwriting typologies and of those belonging to subordinate classes partially alphabetised can not be interpreted in a strict sequential way. The examples provided in two particular moments of the history of Modern Europe, from the year four hundred to the year five hundred and from the year seven hundred to the year eight hundred, confirms the necessity of a critical approximation suitable for the complexity of this proble

    A World Inscribed – Introduction

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    In 1900 or thereabouts, Lorina Bulwer, an inmate of the Great Yarmouth workhouse in the east of England, produced a remarkable and extremely long letter. It was embroidered on samples of different kinds of material which she had sewn together to form a scroll of multicoloured cloth, five metres long (Image 1.1). On her sampler scroll, Lorina stitched a rambling autobiography in which she spat out her anger at being confined to the workhouse, and more specifically to its female lunatic ward. She asserted her identity frequently, repeated her name many times and declared that she was free. Lorina Bulwer’s sampler reminds us of the importance of writing at all levels of society, for both intimate and public purposes as well as in the process of identity formation. It also demonstrates that writing is ubiquitous, and often uses unexpected materials and unorthodox technologies. In this book, we examine the importance of writing at different social levels in a range of historical contexts across the world. As in the case of Lorina Bulwer, the discussion will take account of writing’s institutional frameworks, its personal expressions and the range of material support it has adopted in past societies.info:eu-repo/semantics/publishedVersio

    Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial

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    In the EMN01 trial, the addition of an alkylator (melphalan or cyclophosphamide) to lenalidomide-steroid induction has been prospectively evaluated in transplant-ineligible multiple myeloma patients. After induction, patients were randomly assigned to maintenance treatment with lenalidomide alone or with prednisone continuously. This analysis (median follow-up of 71 months) focused on maintenance treatment and on subgroup analyses according to the International Myeloma Working Group Frailty Score. 217 patients in lenalidomide-dexamethasone, 217 in melphalan-prednisone-lenalidomide and 220 in cyclophosphamide-prednisone-lenalidomide arms were evaluable. 284 (43%) patients were fit, 205 (31%) intermediate-fit and 165 (25%) frail. After induction, 402 patients were eligible for maintenance, (lenalidomide arm: 204; lenalidomide-prednisone: 198). After a median duration of maintenance of 22.0 months, progression-free survival from start of maintenance was 22.2 months with lenalidomide-prednisone vs 18.6 months with lenalidomide (HR 0.85,p=0.14), with no differences across frailty subgroups. The most frequent grade ≥3 toxicity was neutropenia (10% of lenalidomide-prednisone and 21% of lenalidomide patients; p=0.001). Grade ≥3 non-hematologic adverse events were rare (<15%). In fit patients, melphalan-prednisone-lenalidomide significantly prolonged progression-free survival compared to cyclophosphamide-prednisone-lenalidomide (HR 0.72,p=0.05) and lenalidomide-dexamethasone (HR 0.72, p=0.04). Likewise, a trend towards a better overall survival was noted for melphalan-prednisone-lenalidomide and cyclophosphamide-prednisone-lenalidomide, as compared to lenalidomide-dexamethasone. No differences were observed in intermediate-fit and frail patients. This analysis showed positive outcomes of maintenance with lenalidomide-based regimens, with a good safety profile. For the first time, we showed that fit patients benefit from a triplet full-dose regimen, while intermediate-fit and frail patients from gentler regimens. ClinicalTrials.gov registration number: NCT01093196

    MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

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    Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

    Combined fit to the spectrum and composition data measured by the Pierre Auger Observatory including magnetic horizon effects

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    The measurements by the Pierre Auger Observatory of the energy spectrum and mass composition of cosmic rays can be interpreted assuming the presence of two extragalactic source populations, one dominating the flux at energies above a few EeV and the other below. To fit the data ignoring magnetic field effects, the high-energy population needs to accelerate a mixture of nuclei with very hard spectra, at odds with the approximate E2^{-2} shape expected from diffusive shock acceleration. The presence of turbulent extragalactic magnetic fields in the region between the closest sources and the Earth can significantly modify the observed CR spectrum with respect to that emitted by the sources, reducing the flux of low-rigidity particles that reach the Earth. We here take into account this magnetic horizon effect in the combined fit of the spectrum and shower depth distributions, exploring the possibility that a spectrum for the high-energy population sources with a shape closer to E2^{-2} be able to explain the observations

    Measuring the muon content of inclined air showers using AERA and the water-Cherenkov detector array of the Pierre Auger Observatory

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    Studies of the mass composition of cosmic rays and proton-proton interaction cross-sections at ultra-high energies with the Pierre Auger Observatory

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    In this work, we present an estimate of the cosmic-ray mass composition from the distributions of the depth of the shower maximum (Xmax) measured by the fluorescence detector of the Pierre Auger Observatory. We discuss the sensitivity of the mass composition measurements to the uncertainties in the properties of the hadronic interactions, particularly in the predictions of the particle interaction cross-sections. For this purpose, we adjust the fractions of cosmic-ray mass groups to fit the data with Xmax distributions from air shower simulations. We modify the proton-proton cross-sections at ultra-high energies, and the corresponding air shower simulations with rescaled nucleus-air cross-sections are obtained via Glauber theory. We compare the energy-dependent composition of ultra-high-energy cosmic rays obtained for the different extrapolations of the proton-proton cross-sections from low-energy accelerator data

    Study of downward Terrestrial Gamma-ray Flashes with the surface detector of the Pierre Auger Observatory

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    The surface detector (SD) of the Pierre Auger Observatory, consisting of 1660 water-Cherenkov detectors (WCDs), covers 3000 km2 in the Argentinian pampa. Thanks to the high efficiency of WCDs in detecting gamma rays, it represents a unique instrument for studying downward Terrestrial Gamma-ray Flashes (TGFs) over a large area. Peculiar events, likely related to downward TGFs, were detected at the Auger Observatory. Their experimental signature and time evolution are very different from those of a shower produced by an ultrahigh-energy cosmic ray. They happen in coincidence with low thunderclouds and lightning, and their large deposited energy at the ground is compatible with that of a standard downward TGF with the source a few kilometers above the ground. A new trigger algorithm to increase the TGF-like event statistics was installed in the whole array. The study of the performance of the new trigger system during the lightning season is ongoing and will provide a handle to develop improved algorithms to implement in the Auger upgraded electronic boards. The available data sample, even if small, can give important clues about the TGF production models, in particular, the shape of WCD signals. Moreover, the SD allows us to observe more than one point in the TGF beam, providing information on the emission angle
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